Inhibition of tumor growth in vivo by hyaluronan oligomers
نویسندگان
چکیده
منابع مشابه
Inhibition of Tumor Growth and Lung Metastasis of Osteosarcoma in Vivo by Hyaluronan Oligosaccharides
Introduction Hyaluronan (HA) is a large, linear, negatively charged polysaccharide with molecular weights ranging 10-10, interacting with pericellular matrix, and regulating tumor cell biology, such as proliferation, motility, and invasiveness. Manipulation of HA synthesis alters the hyaluronan rich-matrix and malignant properties (1). Numerous studies suggest that HA interacts with specific ce...
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In the last few years, molecular modeling studies have been published that are devoted to a better understanding of the structural flexibility of hyaluronan (HA). Further conformational investigations, however, are needed on this polysaccharide, such as the application of statistical methods to perform enhanced one-step conformational analyses of its subunits. Moreover, the adjustment of assist...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 1998
ISSN: 0020-7136,1097-0215
DOI: 10.1002/(sici)1097-0215(19980729)77:3<396::aid-ijc15>3.3.co;2-w